Peripheral Artery Disease Research Study
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Gene Transfer to Grow New Arteries in Peripheral Artery Disease
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If you have claudication-predictable, reproducible leg muscle pain that ONLY occurs with walking or exercise and goes away with rest-you may be interested in our research study. Claudication usually results from blocked arteries in the leg caused by atherosclerosis, the same disease that causes heart attacks and strokes. Claudication can be treated in many patients with medications or with catheter-based or surgical treatment. In some people, blockages in the arteries are not suitable for catheter-based or surgical approaches. For these people, we are investigating "gene transfer" - injection of engineered DNA (genetic material) that produces proteins that may help grow new arteries and improve blood flow to the legs.
Please read the Detailed Protocol Description to see if you qualify for the study. If you have a diagnosis of PAD with testing and believe that you may be eligible for this experimental treatment, please contact us toll-free at 1-800-411-1222 or e-mail PAD-study@nih.gov. If you do not have a definite diagnosis of PAD and would like to be screened for claudication, and are able to get to the NIH, in Bethesda, Maryland at your own expense, please call the above toll-free number.
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Protocol Information |
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Disease and Treatment Information |
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Peripheral Artery Disease Research Study
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Treatment and Imaging of Peripheral Artery Disease
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If you have intermittent claudication -- muscular leg pain during walking that goes away with rest -- you may be interested in these studies. We can offer non-surgical procedures such as angioplasty and stenting to improve your ability to walk without pain.
There is NO COST to you for evaluation or treatment. If you are eligible, you will undergo a thorough evaluation of your arteries including pressure measurements, treadmill measurements, and magnetic resonance angiography (MRI). We may invite you to participate in related studies, such as measurement of blood flow using MRI and visualization of your arteries using MRI at the same time we perform angioplasty.
For further information, please contact our research coordinator toll-free at 1-877-999-3099, or e-mail PAD-study@nih.gov
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Protocol Information |
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Department of Health
and Human Services
National
Institutes of Health
National Heart, Lung, and Blood
Institute