Clinical Trials

Do you want to help find new treatments for heart failure with preserved ejection fraction? This study is testing whether a medicine called spironolactone can help treat heart failure with preserved ejection fraction when paired with the standard treatment. Spironolactone helps to remove excess water and sodium from the body. To participate in this study, you must be between 50 and 99 years old and diagnosed with heart failure with preserved ejection fraction.

Este estudio explora si un medicamento llamado espironolactona puede mejorar la función cardíaca y pulmonar durante el ejercicio en personas con hipertensión pulmonar. Para participar en este estudio, debe tener entre 18 y 99 años y un tipo de hipertensión pulmonar conocido como hipertensión arterial pulmonar. Este estudio se lleva a cabo en Bethesda (Maryland).

Do you have cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) or want to help someone with the condition? This study aims to learn more about a rare genetic disease called CADASIL. This condition causes small blood vessels in the body to become narrow, which can block blood flow to the brain and lead to a stroke. The study includes blood, urine, and imaging tests. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you or your child have bone marrow failure disease or a telomere biology disorder? This study looks at the long-term effects of bone marrow failure disease and its treatments on organ function. Participants in this study must be 2 years or older with bone marrow failure or telomere biology disorder. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you able to have a magnetic resonance imaging (MRI) scan and want to help people with heart failure? This study is developing new methods for imaging the heart and blood vessels using MRI to improve how healthcare providers diagnose people with heart failure. This study takes place in Maryland and Washington, DC.

Do you have symptoms of a lung disease (such as long-term wet cough, bronchiectasis, or recurrent pneumonia) with no genetic diagnosis? This study aims to develop new ways to diagnose primary ciliary dyskinesia (PCD) or primary immune deficiency (PID), two conditions that can have similar symptoms. Researchers will combine information from genetic testing, lung imaging, and lung function tests to diagnose and tell the difference between these two conditions. Participants in this study must be 5 to 45 years old and must have symptoms of a serious lung disease but no diagnosis. This study is taking place at multiple locations in the United States and in Canada, including the NIH Clinical Center in Bethesda, Maryland.

Are you a male with psoriasis or want to help someone with this condition? This study is exploring whether eating only during certain hours of the day (called time-restricted feeding) can change metabolism and reduce inflammation in the blood of people with mild to moderate psoriasis. To participate in this study, you must be a male between the ages of 18 and 80 with active psoriasis, or be a healthy volunteer. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you an adult who has been exposed to tuberculosis (TB) or wants to help people who have? This study aims to learn how cells within the lungs react when exposed to Tuberculin Purified Protein Derivative, a compound that is commonly used to test for TB exposure. To participate in this study, you must be between the ages of 18 and 64 years old and have either been exposed to TB, but do not have active symptoms, or have never been exposed to TB. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Have you had a genetic test that revealed a change (mutation) in the genes that affect your body's elastic fibers? This study aims to learn more about the impact of changes in connective tissue genes on an individual's overall health. To participate in this study, you or your child must be between the ages of 2 and 100 years old. You must have also had a genetic test that identified changes in a gene that affects elastic fibers (e.g., ELN, LOX, MFAP4, FBLN5 and EFEMP). This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you or your child have severe aplastic anemia? This study tests the safety and effectiveness of two medicines called cyclosporine and eltrombopag in people with severe aplastic anemia. The typical treatment is a combination of three medicines: cyclosporine, eltrombopag, and horse anti-thymocyte globulin. Researchers want to see if starting people at a lower dose of cyclosporine and eltrombopag before giving them horse anti-thymocyte globulin is helpful. Participants in this study must be 4 years or older with severe aplastic anemia. This study is located at the NIH Clinical Center in Bethesda, Maryland.