Clinical Trials

Have you been diagnosed with peripartum cardiomyopathy and are within 5 months of your due date? This study is evaluating the effectiveness of a medicine called bromocriptine to treat peripartum cardiomyopathy, or weakness of the heart muscle that occurs during or shortly after pregnancy. To participate in this study, you must be at least 18 years old, diagnosed with peripartum cardiomyopathy, and within 5 months of your delivery date. This study takes place in Pittsburgh, Pennsylvania.

Do you have heart failure with preserved ejection fraction (HFPEF)? This study is testing the efficacy of a diuretic medicine called spironolactone that stops your body from absorbing too much salt and keeps your potassium levels from dropping too low. Participants of this study must be between 50 and 99 years old and already taking diuretic medicine. This study takes place in multiple locations across the United States and Sweden.

Do you or your child have sickle cell disease and access to a smart phone? This study tests whether a mobile app can help adolescents and young adults who have sickle cell disease take medicine, such as hydroxyurea, correctly and on time. To participate in this study, you or your child must be between 12 and 21 years old, have sickle cell disease, and be currently taking hydroxyurea. This study takes place in Chicago, Illinois.

Do you or your child have sickle cell disease? This study aims to develop a mathematical equation to estimate the functioning of the kidneys in children and adults with sickle cell disease. To participate in this study, you or your child must be between 5 and 50 years old. This study takes place in Birmingham, Alabama; Chicago, Illinois; and Memphis, Tennessee.

Are you an adult with sickle cell disease who doesn't experience pain episodes? This study uses machine learning to identify sickle cell disease patients who may be at increased risk of chronic kidney disease. To participate in this study, you must be between 18 and 65 years old with sickle cell disease and not experiencing any painful episodes. This study takes place in Chicago, Illinois, Winston-Salem, North Carolina, and Memphis, Tennessee.

Are you an adult with heart failure and right bundle branch block (RBBB)? This study will evaluate the effectiveness and benefit of His-bundle-pacing enhanced cardiac resynchronization therapy (His-CRT) versus cardiac resynchronization therapy (BiV-CRT). This study is located in Rochester, New York.

Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. To participate in this study, you or your child must be 12 years old or older. This study takes place in multiple locations across the United States.

Are you a 30- to 55-year-old smoker or non-smoker who would like to support better understanding of COPD risk factors? This study aims to find early signs of COPD in adults who have a high risk of this condition. Researchers will compare results from questionnaires, lung tests, and other tests in people who smoke and in people who do not smoke to look for factors that predict which people will develop COPD. To participate in this study, you must either currently smoke or have no history of smoking. This study takes place in multiple locations in the United States.

Are you a woman 18 years old or older who has been diagnosed with LAM? This study is examining whether long-term treatment with medicine called sirolimus can stop lung damage in women who have LAM. This study takes place at multiple locations in the United States.

Are you between 14 and 22 weeks pregnant, and think that you might have obstructive sleep apnea (OSA) ? This study is testing whether using CPAP to treat obstructive sleep apnea in pregnant women can help lower the risk of hypertensive disorders during pregnancy. To participate in this study, you must be at least 18 years old. This study takes place in multiple locations in the United States.