Clinical Trials

Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. To participate in this study, you or your child must be 12 years old or older. This study takes place in multiple locations across the United States.

Are you a 30- to 55-year-old smoker or non-smoker who would like to support better understanding of COPD risk factors? This study aims to find early signs of COPD in adults who have a high risk of this condition. Researchers will compare results from questionnaires, lung tests, and other tests in people who smoke and in people who do not smoke to look for factors that predict which people will develop COPD. To participate in this study, you must either currently smoke or have no history of smoking. This study takes place in multiple locations in the United States.

Are you a woman 18 years old or older who has been diagnosed with LAM? This study is examining whether long-term treatment with medicine called sirolimus can stop lung damage in women who have LAM. This study takes place at multiple locations in the United States.

Are you between 14 and 22 weeks pregnant, and think that you might have obstructive sleep apnea (OSA) ? This study is testing whether using CPAP to treat obstructive sleep apnea in pregnant women can help lower the risk of hypertensive disorders during pregnancy. To participate in this study, you must be at least 18 years old. This study takes place in multiple locations in the United States.

Are you an adult who has been diagnosed with sleep apnea, prediabetes, and overweight or obesity? This study aims to understand how sleep apnea raises the risk of diabetes. The study will test whether treating sleep apnea with medicines or continuous positive airway pressure (CPAP) helps lower the risk of diabetes in people who have prediabetes. To participate in this study, you must be 20 to 65 years old. This study takes place in Chicago, Illinois.

Are you an African American adult with type 2 diabetes? This study is testing whether mindfulness meditation can help reduce stress and improve sleep. Participants will attend eight meditation classes in person or online and will receive regular text messages to remind them to practice meditation techniques at home. This study takes place in Chicago, Illinois.

Are you a healthy adult? In this clinical trial, researchers are trying to improve the quality of heart CT scans by using new methods to create the images. Researchers will take normal CT images of the heart and compare those images to super high-resolution images made with a super-computer. Healthy adults aged 18 years or older may be able to participate. The study is taking place at the NIH Clinical Center in Bethesda, Maryland.

Are you at least 18 years old and scheduled for a CT of the chest, abdomen, and pelvis? In this study, researchers want to learn if new CT imaging methods with less radiation make images that are similar to traditional ways. If you are at least 18 and your doctor has said you need a CT scan of the chest, abdomen, or pelvis, you may be able to participate. This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.

The goal of the study is to look at the relationship between how individuals with Sarcoidosis take the sarcoidosis medicines and how it affects the disease, to evaluate any factors that may make individuals not want to take the medicines, and to develop and refine ways to help support individuals with Sarcoidosis especially when it comes to the medicines. The overall hypothesis is higher medication adherence will be associated with better clinical outcomes in sarcoidosis. The investigators will enroll 150 patients with biopsy proven pulmonary sarcoidosis for at least one year who are on any oral treatment regimen for at least six months into a 12-month longitudinal study.

The purpose of this study is to see if adding a drug called Regadenoson to the EVLP circulation reservoir during perfusion of marginal donor lungs will help increase the likelihood that the donor lungs will become usable for transplantation.