Clinical Trials

Do you or your child have cardiovascular disease or want to help research? This study aims to identify better MRI methods and new ways of imaging cardiovascular disease to understand cardiovascular and brain function. Researchers are also interested in seeing whether gadolinium, the commonly used MRI contrast agent, stays in the body long after an MRI is performed. To participate in this study, you or your child should be healthy or have a cardiovascular condition and be at least 7 years old.

Do you or your child have a disease affecting the blood vessels? This study is collecting blood samples to study the role of inflammation in diseases of the blood vessels, including coronary heart disease and sickle cell disease. To participate, you or your child must be at least 2 years old and either be healthy or have a disease affecting the blood vessels. This study is located in Bethesda, Maryland.

Do you have depression symptoms and have been diagnosed with coronary heart disease? This study aims to find out whether an online tool can help improve symptoms of depression in people who have coronary heart disease and encourage them to start treatment for depression. To participate in this study, you must be at least 21 years old and have symptoms of depression and a history of coronary heart disease. This study is located in New York, New York.

Are you able to have a magnetic resonance imaging (MRI) scan and want to help people with heart failure? This study is developing new methods for imaging the heart and blood vessels using MRI to improve how healthcare providers diagnose people with heart failure. This study takes place in Maryland and Washington, DC.

Do you have a scheduled CT scan for heart disease? This study will look at different ways to take pictures of the heart and blood vessels using computed tomography (CT) that use less radiation than traditional scans. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you an adult with obesity and at high risk of heart and blood vessel disease? This study is testing a new program to help people who have obesity stick to their healthy eating plan. Researchers from this study are developing a program that will predict when participants are most likely to stop making healthy food choices and will send messages to remind participants of their weight loss goals. To participate in this study, you must be 18 to 70 years old, have overweight or obesity, and be at high risk of heart and blood vessel diseases. This study takes place in Providence, Rhode Island.

Have you experienced a cardiac event in the past 6 months? This study assesses the efficacy of combining center-based and remote- or home-based cardiac rehabilitation sessions. Many patients who require cardiac rehabilitation, including those with angina myocardial infarction, heart failure, heart valve disease, and coronary heart (artery) disease, do not complete the necessary amount of rehabilitation sessions when done in a center-based environment. Researchers are investigating whether a combination approach will help. To participate in this study, you must be between 18 and 85 years old. This study takes place in Detroit, Michigan.

Are you in need of a heart or lung transplant or have you had one in the past 3 months? Have you undergone a lung or heart transplant in the past 3 months or are you a candidate for heart or lung transplant? Some people with advanced heart and lung disease have heart and lung transplants but these new organs are often rejected. When this happens, patients must have repeated biopsies, which are invasive and expensive. Researchers in this clinical study want to see if a blood test can predict organ rejection and take the place of biopsies. To participate, you must be 18 to 80 years old and be a candidate for heart or lung transplant or have had a heart or lung transplant no more than three months ago. The study is taking place in Bethesda, Maryland, at the NIH Clinical Center, as well as in Baltimore, Maryland, and Falls Church, Virginia.