Skip banner and top navigation
NHLBI Logo and Link
National Heart, Lung, and Blood Institute: People, Science, Health
 HOME  SITE INDEX  CONTACT US
  
  Patient Recruitment - Myelodysplastic Syndromes (MDS)
TIPS     ADVANCED SEARCH
 

Research Studies        
Alemtuzumab (Campath-1H) for Myelodysplastic Syndrome (MDS)   Non-myeloablative stem cell transplant for patients with myelodysplastic syndrome   Stem Cell Transplant to Treat Myelodysplastic Syndrome (MDS)  
Eltrombopag in Myelodysplastic syndrome (MDS) patients with low platelets   Partially Matched DLI to Treat Relapsed MDS   Umbilical Cord Transplant to Treat Myelodysplastic Syndrome (MDS)
Escalating Doses of ON 01910.Na for Myelodysplastic Syndrome (MDS)  

Myelodysplastic Syndromes (MDS) Research Study

Alemtuzumab (Campath-1H) for Myelodysplastic Syndrome (MDS)

Hematologists at the National Heart, Lung, and Blood Institute are investigating a new treatment for myelodysplastic syndrome (MDS). The study drug, a monoclonal antibody, may help increase blood counts, reduce anemia symptoms, and/or reduce dependence on transfusions. If eligible to participate, consenting subjects will receive an intravenous infusion of study medication alemtuzumab (Campath-1H) once a day for 10 days. Subjects will be admitted to the NIH Clinical Center hospital for study drug initiation. If the study drug infusion is tolerated well, the subject may be discharged and receive the remainder of the treatment course as an outpatient.

If you have been diagnosed with MDS and are 18 years or older, you may be able to participate in this clinical trial. To find out if you qualify, please call our study coordinator at 301-594-4180 or email us at BloodStudy@nhlbi.nih.gov

 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Eltrombopag in Myelodysplastic syndrome (MDS) patients with low platelets

If you have been diagnosed with myelodysplastic syndrome, are18 years old or older, and have a low platelet count, you may be able to participate in a NIH sponsored clinical trial evaluating eltrombopag, a new FDA approved drug that has been shown to help the bone marrow produce more platelets in patients with another disorder that causes a low platelet count, immune thrombocytopenia (ITP). We are studying whether or not this drug can increase the platelet count and/or reduce the need for platelet transfusions in patients with myelodysplastic syndrome.

If you qualify for study participation, you will take eltrombopag pills by mouth once a day for three months. While you are taking eltrombopag and for 30 days after you discontinue the drug we will monitor you closely for side effects. You will need to been seen at least once a month at the NIH, and weekly for blood count monitoring either with your home physician or at the NIH. To find out if you qualify or for more information, please contact our study coordinator 301-594-4180 or email us at BloodStudy@nhlbi.nih.gov


 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Escalating Doses of ON 01910.Na for Myelodysplastic Syndrome (MDS)

If you are between the ages of 18 and 85 and have been diagnosed with Myelodysplastic Syndrome (MDS), you may be able to participate in a clinical trial evaluating a new experimental anti-cancer therapy. This study will determine what dose and which dosing schedule of this new drug is safe. We will also evaluate whether or not this drug can slow progression of your illness, improve blood counts, and/or reduce the need for transfusions of blood and/or platelets.

Study participants will receive 3-5 days of drug infusion ( 1 cycle) every other week for a minimum of 2 cycles and a maximum of 8 cycles.

To find out if you qualify or for more information, please contact our study coordinator at 301-594-4180 or email us at BloodStudy@nhlbi.nih.gov


 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Non-myeloablative stem cell transplant for patients with myelodysplastic syndrome

If you have been diagnosed with MDS, you may be able to participate in a stem cell transplant clinical trial designed to evaluate methods to decrease graft versus host disease, promote engraftment, and improve immune system recovery following a bone marrow stem cell transplant procedure.

You must have an HLA-matched family member to participate. You will be given chemotherapy followed by a transfusion of stem cells and lymphocytes from your donor, which will replace your immune system with the immune system of your healthy donor. Post transplant therapy is designed to reduce the risk of graft versus host disease.

We do the blood testing free of charge to see if your family member is a match. We pay for all medical costs related to the transplant procedure. You must be available to live near NIH for approximately 3 months. We also provide a daily allowance to help with living expenses while you are on the study and living away from home.

To inquire about eligibility, contact our research coordinator at (301) 594-8013 or by e-mail BloodStudy@nhlbi.nih.gov
 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Partially Matched DLI to Treat Relapsed MDS

If you or someone you know is diagnosed with myelodysplastic syndrome (MDS) and have relapsed within 6 months of receiving a stem cell transplant, you may be able to participate in our clinical trial designed to evaluate the effectiveness of a partially HLA matched infusion of donor lymphocytes (DLI). Specifically, we are testing whether giving an infusion of donor lymphocytes from a partially matched family member will maximize the antileukemia effect of following an HLA matched allogeneic stem cell transplant. To achieve at least temporary engraftment of the DLI and disease control, cyclophosphamide and fludarabine immunosuppression will be given prior to the DLI.

To find out if you qualify, please contact our research coordinator at (301) 496-3841 or by email at BloodStudy@nhlbi.nih.gov

 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Stem Cell Transplant to Treat Myelodysplastic Syndrome (MDS)

If you (or someone you know) have been diagnosed with Myelodysplastic Syndrome, you may be able to participate in our clinical trial designed to investigate methods of making stem cell transplant procedures safer and more effective. Specifically, we are testing whether special treatment of donor stem cells and delaying the transfusion of donor immune cells will reduce complications and improve transplant outcome. You must have an HLA-matched brother or sister who is willing to participate as a donor in order to participate in this study.

To find out if you qualify, please contact our research coordinator at (301) 496-3841 or by email at BloodStudy@nhlbi.nih.gov

 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 

Myelodysplastic Syndromes (MDS) Research Study

Umbilical Cord Transplant to Treat Myelodysplastic Syndrome (MDS)

If you (or someone you know) has been diagnosed with myelodysplastic syndrome, you may be able to participate in our clinical trial designed to investigate methods of making stem cell transplant procedures safer and more effective for a wide number of diseases and disorders. In this study, we will evaluate the safety and effectiveness using a different type of stem cell transplant procedure, specifically, co-infusion of peripheral blood stem cells from a family member and cord blood stem cells from an unrelated donor.

You must have a family member who is willing to participate as a stem cell donor as well as the availability of an HLA matched umbilical cord blood unit (the NIH will conduct the search and procurement) in order to participate in this study.

To find out if you qualify, please contact our research coordinator at (301) 594-8013 or by email at BloodStudy@nhlbi.nih.gov

 
Email This Study To A Friend       View/Print PDF Version Of This Study

Protocol Information

Disease and Treatment Information

Support Groups
 

 
 
Spacer

NHLBI HOME · ACCESSIBILITY INFORMATION · NHLBI AT THE CLINICAL CENTER · PRIVACY STATEMENT · SUPPORTED BROWSERS · WEB TECHNICAL CONTACT· v1.2.0.1